Friability describes the mass reduction of a solid dosage form such as compressed, uncoated tablets occurring when subjected to mechanical strain during handling such as tumbling, vibration, or rubbing in a blister packaging. According to USP <1216> and Ph. Eur. 2.9.7, a maximum mean weight loss of not more than one percent (1%) is considered acceptable for most procucts. Effervescent tablets and chewable tablets may have different specifications for friability. Measurement of tablet friability supplements other physical strength measurements such as abrasion tests and tablet hardnesss measuring (breaking force determination).
