Ultra-High Sensitivity:

By incorporating newly improved ion optics and collision cell technology, the LCMS-8040
provides higher multiple reaction monitoring (MRM) sensitivity. A five-fold increase in sensitivity
(reserpine, S/N ratio), as compared with that of LCMS-8030 has been achieved by improving ion
focusing and minimizing ion losses between multi-pole lenses. These improvements also yield
higher sensitivity for scan mode measurements. This higher sensitivity expands the potential
range of LC/MS/MS applications.


The LCMS-8040 was designed to provide significantly higher sensitivity while maintaining the
high speed offered by the LCMS-8030. Ultrafast MRM transition speeds, up to 555 MRMs per
second, are achieved by Shimadzu’s UFsweeper collision cell technology, proprietary
high-precision quadrupole machining capabilities, and unique high voltage power supply
technology. In addition, the LCMS-8040 features the fast polarity switching at 15 msec.
With this high-speed performance, the LCMS-8040 can dramatically improve analytical

Ultra-High Reliability:

MRM optimization in Shimadzu’s LCMS systems is based on a rapid series of automated flow
injection analyses, requiring only minutes to perform. Multiple compounds can be optimized
in an unattended sequence, freeing the analyst from tedious work. MRM parameters
optimized for the LCMS-8030 can be transferred to the LCMS-8040, making it possible to
transfer methods between systems. The LCMS-8040 offers the same ease of maintenance
benefits as the LCMS-8030, and all consumables, such as desolvation lines (DL) and ESI
capillaries, are interchangeable as well