Health Sciences Authority (HSA) of Singapore on 4th December 2019 recalled three out of 46
locally marketed Metformin medicines after presence of NDMA “above the
internationally acceptable level” and this came into . Subsequently, both the
US Food and Drug (FDA) and the European Medicines Agency (EMA) have
released regular updated into their into the causes of medicine contamination.
Metformin (Figure 1) is the -line drug control of high blood sugar levels in patients with type 2
diabetes, particularly people who are overweight.
Here, a single LC-MS/MS method is developed for the quantitation of six nitrosamines namely
NDMA, NDEA, NDIPA, NMBA, NEIPA and NDBA (Figure 2) in Metformin drug